Vigabatrin

About

Vigabatrin is an anti convulsant used to control seizures/fits. It can be useful in several types of seizures, such as focal and generalised.  Vigabatrin has been found to be effective in Infantile Spasms and in patients with Tuberous Sclerosis.

Vigabatrin must be prescribed by a doctor. You should never give your child anyone else's medications.

 

Disclaimer

The information provided in this handout is limited and does not replace the need for a medical consultation. It is very important you speak to your doctor about all aspects of your medication including side effects when medication is first prescribed. Report any concerns to your doctor promptly.

Side effects

All medications have side effects. Not everyone will experience side effects.

Below are some of the possible side effects your child may experience.

  • Decreased peripheral vision (see less at the edges of their vision). This is a potential serious side effect and requires monitoring by an eye doctor on a regular basis
  • Sedation
  • Dizziness, ataxia
  • Double vision
  • Memory, learning and behavioural difficulties
  • Crankiness
  • Depression
  • Fatigue
  • Nausea and abdominal pain
  • Weight gain
  • Headache

Rare Side Effects

  • Inflammation of the optic nerve (the nerve of the eye)
  • Rash
  • May cause increase in seizure frequency particularly myoclonic or absence seizures
  • Psychosis

Interactions

Your Doctor will check and make sure that other drugs your child is taking are compatible with Vigabatrin. This is also important if you are giving your child herbal or complementary medicines. The doctor can check to make sure they are compatible.

Vigabatrin may interact with other anticonvulsants. Your doctor will monitor these potential problems.

Need-to-know

Monitoring and Levels

  • Eye testing before starting the drug and continued monitoring of eyes throughout treatment.
  • An electric test called the ERG is used in young patients or those with developmental disability.

Pregnancy and contraception

  • Vigabatrin can rarely cause malformations of a baby in the uterus.
  • If a pregnancy is planned, a discussion with your neurologist is recommended.
  • For further information, refer to the Contraception and Pregnancy section.