Lamotrigine

About

Lamotrigine is an anti convulsant used to control seizures/ fits. It is most commonly used in generalised epilepsies in children. It has also been found to be effective in focal seizure and secondary generalised tonic clonic seizure disorders.

Lamotrigine must be prescribed by a doctor. You should never give your child anyone else's medications.

Disclaimer

The information provided in this handout is limited and does not replace the need for a medical consultation. It is very important you speak to your doctor about all aspects of your medication including side effects when medication is first prescribed. Report any concerns to your doctor promptly.

Side effects

All medications have side effects. Not everyone will experience side effects.

Below are some of the possible side effects your child may experience:

Rash

  • Most serious. If your child develops any rash, red eyes, red mouth, or blisters around the mouth, nose or lips, please contact your doctor immediately or go to the nearest Emergency Department (ED). The drug needs to be stopped immediately under medical supervision. Patients on sodium valproate (Epilim) are more at risk. Rashes are potentially very serious. 

Common side effects

  • Insomnia may occur. If this occurs sometimes it may be better to give the dose earlier in the day. Discuss with your doctor.
  • Drowsiness
  • Ataxia (unsteady walking)
  • Double Vision and blurred vision
  • Headache
  • Tremors
  • Blood disorders
  • Behavioural changes

Patients can feel better on Lamotrigine as it is a mood stabiliser.

Rare side effects

  • Liver and blood abnormalities

Interactions

Your Doctor will check and make sure that other drugs your child is taking are compatible with Lamotrigine. This is also important if you are giving your child herbal or complementary medicines. The doctor can check to make sure they are compatible.

Care must be taken when combining Lamotrigine with Sodium Valproate.

Need-to-know

Monitoring and Levels

No blood monitoring is required.  If you have any questions please ask your doctor.

Pregnancy and contraception

  • Lamotrigine may influence the oral contraceptive pill. It can decrease its effectiveness.
  • Lamotrigine can have teratogenic effects on the unborn child.
  • If a pregnancy is planned, a discussion with your neurologist is recommended. This is an important issue.
  • For further information, refer to the Contraception and Pregnancy section.